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NEUROREGENERATION INSTITUTE
Director: Prof. Ole Isacson, Biography and Research
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IN THE NEWS AND MEDIA (click here for more news)

Long-term survival of dopamine neurons in patients: Encouraging news for future stem-cell based dopamine neuron transplants
BBC Sponsored Audio Link for Interview with Dr. Isacson
AlzForum Article
International News Articles

Dr. Isacson elected Fellow of the American Association for the Advancement of Science
View AAAS Annoucement

Dr. Isacson presents stem cell research at Vatican Conference in Rome
McLean Press Release
Conference Program

Dr. Isacson selected for Executive Scientific Advisory Board of the Michael J. Fox Foundation
ESAB Membership

Getting Closer to a Stem Cell Therapy for Parkinson’s Disease
Neuroregeneration Lab’s Parkinson's Disease Research highlighted in HSCI’s Stem Cell Matrix

Update on Parkinson’s Disease Research at Harvard Stem Cell Institute
Click here to view article

Neuroregeneration Lab's ALS Research Featured in New Video
Click here to view video

Mitochondrial Energetics Energize Parkinson's Disease iPSC-derived
Neural Study
Harvard Stem Cell Institute Interviews Dr. Isacson

Personalized Medicine Closer to Reality
Harvard Gazette article

PDiPS Consortium and Isacson lab show cells from different patients have unique drug responses
Press release July 4, 2012

Molecular and Cellular Neuroscience (MCN), Ole Isacson, Editor in Chief
View Table of Contents for the latest issue of Molecular and Cellular Neuroscience

MCN Special Issue: Mitochondrial function and dysfunction in neurodegeneration, edited by Hibiki Kawamata, Giovanni Manfredi and Marilena D'Aurelio
View Table of Contents

FRONTLINE: A Report on Parkinson's Disease
Update on PBS: June, 2012

Neuroregeneration Institute Intensifies Quest for New Parkinson's Treatments

NIH Grant Awarded for PDiPS Cell Consortium
PDiPS Consortium Abstract PDF
PDiPS Consortium website

Neuroregeneration Institute lands 6 new Michael J. Fox Foundation competitive research awards
Click here to see Dr. Ole Isacson's MJFF website announcement and specific studies underway
Click here to see Dr. Penelope Hallett's MJFF website announcement and specific studies underway

Drs. Ole Isacson and Penny Hallett receive new funding from CHDI for Huntington's disease research
CHDI Foundation website

Dr. Ole Isacson receives new federal grant for innovative ALS work
ALS Abstract PDF

RECENT RESEARCH ARTICLES FROM NEUROREGENERATION INSTITUTE (click here for full list of publications)

Long-term health of dopaminergic neuron transplants in Parkinson's disease patients
Cell Reports, June 5, 2014, doi:10.1016/j.celrep.2014.05.027

Abstract
PDF File

Progressive axonal transport and synaptic protein changes correlate with behavioral and neurpathological abnormalities in the heterozygous Q175KI mouse model of Huntington's disease
Human Molecular Genetics, April 30, 2014, doi: 10.1093/hmg/ddu166

Abstract
PDF File

Hallett Cover 2012LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction
Neurobiology of Disease, 2014 • 62:381-386

Abstract
PDF File

 

 

 

 

 

 

 

 

 

 

Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC-, hiPSC, and Non-Human Primate iPSC-Derived Dopaminergic Neurons
Stem Cells, 2013 • 31:1548-1562

Abstract
PDF File

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease
Science Transl Med, July 4, 2012 • 4:52-64

Abstract
PDF File


Hallett Cover 2012

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits.
Neurobiol Dis,Apr. 19, 2012 •47:258-67.

Abstract
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Viral and Inflammatory Triggers of Neurodegenerative Diseases.
Science Transl Med, Feb 15, 2012 • 4:121-3.

Abstract
PDF File

Using stem cells and iPS cells to discover new treatments for Parkinson's disease.
Parkinsonism Relat Disord, Jan 18, 2012. Suppl 1:S14-6.

Abstract fromPubMed
PDF File

Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression.
Mol Cell Neurosci, 2012 • 49:230-239

Abstract from PubMed

PDF File

Oct4-induced reprogramming is required for adult brain neural stem cell differentiation into midbrain dopaminergic neurons.
PLoS One, Published online May 31, 2011 • 6(5): e19926.
Abstract from PubMed
PDF File


Development of histocompatible primate induced pluripotent stem cells for neural transplantation.
Stem Cells, May 23, 2011 • 29(7):1052-63.
Abstract from PubMed
PDF File


Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson's disease.
The Journal of Neurology,
August, 2011 • 258(8):1393-405.
Abstract from PubMed
PDF File


The Toll-Like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration.
The Journal of Neuroscience, December 1, 2010 • 30(48): 16091- 101.
Abstract from JNeurosci
PDF File


Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.
Proceedings of the National Academy of Sciences, September 2010 • 107: 15921- 26.
Abstract from PNAS
PDF File




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