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Director: Prof. Ole Isacson, Biography and Research
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IN THE NEWS AND MEDIA (click here for more news)

Neuroscience Regenerative Medicine Changing Healthcare: Most Innovative
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New data demonstrate for the first time that an age-dependent reduction in glucocerebrosidase activity may lower the threshold for developing Parkinson's disease
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Harvard Gazette reports on Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease
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Nature Biotechnology reviews the use of iPSCs for drug discovery and modeling of familial Parkinson's disease in cell culture
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Long-term survival of dopamine neurons in patients: Encouraging news for future stem-cell based dopamine neuron transplants
BBC Sponsored Audio Link for Interview with Dr. Isacson
AlzForum Article
International News Articles

Dr. Isacson elected Fellow of the American Association for the Advancement of Science
View AAAS Annoucement

Dr. Isacson presents stem cell research at Vatican Conference in Rome
McLean Press Release
Conference Program

Dr. Isacson selected for Executive Scientific Advisory Board of the Michael J. Fox Foundation
ESAB Membership

Getting Closer to a Stem Cell Therapy for Parkinson’s Disease
Neuroregeneration Lab’s Parkinson's Disease Research highlighted in HSCI’s Stem Cell Matrix

Update on Parkinson’s Disease Research at Harvard Stem Cell Institute
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Neuroregeneration Lab's ALS Research Featured in New Video
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Mitochondrial Energetics Energize Parkinson's Disease iPSC-derived
Neural Study
Harvard Stem Cell Institute Interviews Dr. Isacson

Personalized Medicine Closer to Reality
Harvard Gazette article

PDiPS Consortium and Isacson lab show cells from different patients have unique drug responses
Press release July 4, 2012

Molecular and Cellular Neuroscience (MCN), Ole Isacson, Editor in Chief
View Table of Contents for the latest issue of Molecular and Cellular Neuroscience

MCN Special Issue: Mitochondrial function and dysfunction in neurodegeneration, edited by Hibiki Kawamata, Giovanni Manfredi and Marilena D'Aurelio
View Table of Contents

FRONTLINE: A Report on Parkinson's Disease
Update on PBS: June, 2012

Neuroregeneration Institute Intensifies Quest for New Parkinson's Treatments

NIH Grant Awarded for PDiPS Cell Consortium
PDiPS Consortium Abstract PDF
PDiPS Consortium website

Neuroregeneration Institute lands 6 new Michael J. Fox Foundation competitive research awards
Click here to see Dr. Ole Isacson's MJFF website announcement and specific studies underway
Click here to see Dr. Penelope Hallett's MJFF website announcement and specific studies underway

Drs. Ole Isacson and Penny Hallett receive new funding from CHDI for Huntington's disease research
CHDI Foundation website

Dr. Ole Isacson receives new federal grant for innovative ALS work
ALS Abstract PDF


Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease
Cell Stem Cell, 2015 • 16, 269-274

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Progressive decline of glucocerebrosidase in aging and Parkinson's disease
Annals of Clinical and Translational Neurology, 2015, Apr2(4):433-8, doi: 10.1002/acn3.177

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Long-term health of dopaminergic neuron transplants in Parkinson's disease patients
Cell Reports, 2014, 7:1755-61, doi:10.1016/j.celrep.2014.05.027

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Progressive axonal transport and synaptic protein changes correlate with behavioral and neurpathological abnormalities in the heterozygous Q175KI mouse model of Huntington's disease
Human Molecular Genetics, April 30, 2014, doi: 10.1093/hmg/ddu166

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Hallett Cover 2012LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction
Neurobiology of Disease, 2014 • 62:381-386

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Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC-, hiPSC, and Non-Human Primate iPSC-Derived Dopaminergic Neurons
Stem Cells, 2013 • 31:1548-1562

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Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease
Science Transl Med, July 4, 2012 • 4:52-64

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Hallett Cover 2012

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits.
Neurobiol Dis,Apr. 19, 2012 •47:258-67.

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Viral and Inflammatory Triggers of Neurodegenerative Diseases.
Science Transl Med, Feb 15, 2012 • 4:121-3.

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Using stem cells and iPS cells to discover new treatments for Parkinson's disease.
Parkinsonism Relat Disord, Jan 18, 2012. Suppl 1:S14-6.

Abstract fromPubMed
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Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression.
Mol Cell Neurosci, 2012 • 49:230-239

Abstract from PubMed

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Oct4-induced reprogramming is required for adult brain neural stem cell differentiation into midbrain dopaminergic neurons.
PLoS One, Published online May 31, 2011 • 6(5): e19926.
Abstract from PubMed
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Development of histocompatible primate induced pluripotent stem cells for neural transplantation.
Stem Cells, May 23, 2011 • 29(7):1052-63.
Abstract from PubMed
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Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson's disease.
The Journal of Neurology,
August, 2011 • 258(8):1393-405.
Abstract from PubMed
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The Toll-Like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration.
The Journal of Neuroscience, December 1, 2010 • 30(48): 16091- 101.
Abstract from JNeurosci
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Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.
Proceedings of the National Academy of Sciences, September 2010 • 107: 15921- 26.
Abstract from PNAS
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