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NEUROREGENERATION INSTITUTE
Director: Prof. Ole Isacson, Biography and Research
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IN THE NEWS AND MEDIA (click here for more news)

Fighting Parkinson's in the Lab
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NPR Interviews Dr. Isacson about Mohammed Ali's fight with Parkinson's disease
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National Stem Cell Foundation and Michael J. Fox Foundation Partner to Support Parkinson's Cell Replacement Therapy
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MJFF Parkinson podcast with Dave Iverson and Ole Isacson 2016: The stem cells basics
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Ole Isacson Lecture on Parkinson's disease in a Dish: Induced Pluripotent Stem Cell Models of Disease SFN Neurobiology of Disease Workshop graduate course
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Lysosomes to combat Parkinson's diseases
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WMIF 2015 | Regeneration, Cell Therapy, and Neurocare: Products? Delivery?
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New data demonstrate for the first time that an age-dependent reduction in glucocerebrosidase activity may lower the threshold for developing Parkinson's disease
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Dr. Ivar Mendez and Dr. Ole Isacson show cell transplantation brain surgery for Parkinson's disease
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Harvard Gazette reports on Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease
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Nature Biotechnology reviews the use of iPSCs for drug discovery and modeling of familial Parkinson's disease in cell culture
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Ole Isacson - Keynote speech at Innovative Medicines Initiative (IMI) Stakeholder forum 2014 - Stem Cells: a global perspective
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Long-term survival of dopamine neurons in patients: Encouraging news for future stem-cell based dopamine neuron transplants
BBC Sponsored Audio Link for Interview with Dr. Isacson
AlzForum Article
International News Articles

Molecular and Cellular Neuroscience (MCN), Ole Isacson, Editor in Chief
View Table of Contents for the latest issue of Molecular and Cellular Neuroscience

MCN Special Issue: Mitochondrial function and dysfunction in neurodegeneration, edited by Hibiki Kawamata, Giovanni Manfredi and Marilena D'Aurelio
View Table of Contents


RECENT RESEARCH ARTICLES FROM NEUROREGENERATION INSTITUTE (click here for full list of publications)

In vivo modeling of neuronal function, axonal impairment and connectivity in neurodegenerative and neuropsychiatric disorders using induced pluripotent stem cells.
Korecka
et al.
Mol Cell Neurosci, 2015 • Dec. 10, 2015, doi: 10.1016/j.mcn.2015.12.004
Abstract from PubMed
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Glucocerebrosidase gene therapy prevents a-synucleinopathy of midbrain dopamine neurons.
Rocha et al.

Neurobiol Dis, 2015 • Sept. 25, 2015, doi: 10.1016/j.nbd.2015.09.009
Abstract from PubMed
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Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition.
Smith et al.

Mol Neurobiol, 2015 • Sept. 23, 2015, doi: 10.1007/s12035-015-9435-4
Abstract from PubMed
PDF File

Progressive decline of glucocerebrosidase in aging and Parkinson's disease.
Rocha et al. 

Ann Clin Transl Neurol, 2015 23(6), Apr. 2, 2015, doi: 10.1002/acn3.177
Abstract from PubMed
PDF File

Sustained Systemic Glucocerebrosidase Inhibition Induces Brain a-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice.
Rocha et al. 

Antioxidants & Redox Signaling, 2015 • 23(6), doi: 10.1089/ars.2015.6307
Abstract from PubMed
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A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).
Smith et al.

PLoS One, 2015 • 10(3), Mar. 27, 2015, doi: 10.1371/journal.pone.0121072
Abstract from PubMed
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Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease
Cell Stem Cell, 2015 • 16, 269-274

Abstract
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Long-term health of dopaminergic neuron transplants in Parkinson's disease patients
Cell Reports, 2014, 7:1755-61, doi:10.1016/j.celrep.2014.05.027

Abstract
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Progressive axonal transport and synaptic protein changes correlate with behavioral and neurpathological abnormalities in the heterozygous Q175KI mouse model of Huntington's disease
Human Molecular Genetics, April 30, 2014, doi: 10.1093/hmg/ddu166

Abstract
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LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction
Neurobiology of Disease, 2014 • 62:381-386

Abstract
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Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease
Science Transl Med, July 4, 2012 • 4:52-64

Abstract
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Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits.
Neurobiol Dis,Apr. 19, 2012 •47:258-67.

Abstract
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Viral and Inflammatory Triggers of Neurodegenerative Diseases.
Science Transl Med, Feb 15, 2012 • 4:121-3.

Abstract
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Using stem cells and iPS cells to discover new treatments for Parkinson's disease.
Parkinsonism Relat Disord, Jan 18, 2012. Suppl 1:S14-6.

Abstract fromPubMed
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Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression.
Mol Cell Neurosci, 2012 • 49:230-239

Abstract from PubMed

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Oct4-induced reprogramming is required for adult brain neural stem cell differentiation into midbrain dopaminergic neurons.
PLoS One, Published online May 31, 2011 • 6(5): e19926.
Abstract from PubMed
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Development of histocompatible primate induced pluripotent stem cells for neural transplantation.
Stem Cells, May 23, 2011 • 29(7):1052-63.
Abstract from PubMed
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Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson's disease.
The Journal of Neurology,
August, 2011 • 258(8):1393-405.
Abstract from PubMed
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The Toll-Like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration.
The Journal of Neuroscience, December 1, 2010 • 30(48): 16091- 101.
Abstract from JNeurosci
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Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.
Proceedings of the National Academy of Sciences, September 2010 • 107: 15921- 26.
Abstract from PNAS
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