  
|
 Director: Prof. Ole Isacson, Biography and Research Search Contact and Directions |
  |
||
|
Virtual
Tour of McLean |
|
|||
| ||||||||||
IN THE NEWS AND MEDIA Reprogrammed adult skin cells treat Parkinson's disease in animal model Stem Cells from Skin Treat
Brain Disease in Rats Parkinson's Brain Cell Transplants
Last for Years FRONTLINE: A Report on Parkinson's
Disease March/April 2008 Neurosurgical
Focus Interview Partnership is a Real No-Brainer;
Dal-Harvard to Work Together on Brain Repair RECENT RESEARCH ARTICLES Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years
|
RECENT PUBLICATIONS
Embryonic Stem (ES) Cell-derived Pitx3-eGFP Midbrain Dopamine Neurons Survive Enrichment by FACS and Function in an Animal Model of Parkinson's Disease.
Hedlund et al. Stem Cells, 2008 Abstract
PDF
Influence of cell preparation and target location on the behavioral recovery after striatal transplantation of fetal dopaminergic neurons in a primate model of Parkinson's disease.
Redmond et al. Neurobiology of Disease, 2007 Abstract
PDF
Cell therapy and stem cells
in animal models of motor neuron disorders.
Hedlund et al. Eur. J. Neurosci. 2007 Abstract PDF
Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.
Inoue et al. Proc. Natl. Acad. Sci., August 28 2007 Abstract
PDF
An Endogenous Serine/Threonine Protein Phosphatase
Inhibitor, G-Substrate, Reduces Vulnerability in Models of
Parkinson’s Disease.
Chung et al. J. Neurosci., August 2007 Abstract
PDF
In vivo evidence of D(3) dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias.
Sánchez-Pernaute et al. Neurobiol Dis., May 2007 Abstract
PDF
Markers and Methods for Cell Sorting of Human Embryonic Stem Cell-derived Neural Cell Populations.
Pruszak et al. Stem Cells, June 2007 Abstract
PDF
Selection of Embryonic Stem Cell-Derived Enhanced Green Fluorescent Protein-Positive Dopamine Neurons Using the Tyrosine Hydroxylase Promoter Is Confounded by Reporter Gene Expression in Immature Cell Populations.
Hedlund et al. Stem Cells, May 2007 Abstract
PDF
Inhibition of the dopamine D1 receptor signaling by PSD-95.
Zhang et al. J. Biol. Chem., March 2007 Abstract
PDF
Proteasome Activator Enhances Survival of Huntington's Disease Neuronal Model Cells.
Seo et al. PLoS ONE February 2007 Abstract
PDF
Enhanced Yield of Neuroepithelial Precursors and Midbrain-Like Dopaminergic Neurons from Human Embryonic Stem Cells Using the Bone Morphogenic Protein Antagonist Noggin.
Sonntag et al. Stem Cells Vol. 25 No. 2. February 2007 Abstract
PDF
Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft.
Ferrari et al. Eur. J. Neurosci. October 2006 Abstract
PDF
Neural precursors derived
from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain
the potential to differentiate into dopaminergic neurons after expansion in
vitro.
Chung et al. Stem Cells. March 16, 2006 Abstract
PDF
Specific microRNAs modulate ES
cell-derived neurogenesis.
Krichevsky et al. Stem
Cells Vol. 24 No. 4 April 2006
Abstract
PDF
Long-term survival of dopamine
neurons derived from parthenogenetic primate embryonic stem cells (Cyno1) after
transplantation.
Sanchez-Pernaute et al. Stem Cells. June 7, 2005 Abstract
PDF
Cell type specific gene
expression of midbrain dopaminergic neurons reveals molecules involved in their
vulnerability and protection.
Chung CY et al. Hum Mol Genet. May 11, 2005 Abstract
PDF
Cell type analysis of functional
fetal dopamine cell suspension transplants in the striatum and substantia nigra
of patients with Parkinson's disease.
Mendez et al. Brain Advance Access published online on May 4, 2005 Abstract
PDF
Netrin-1 and slit-2 regulate
and direct neurite growth of ventral midbrain dopaminergic neurons.
Lin et al. Mol Cell Neurosci. March 28, 2005 Abstract
PDF
Context-dependent neuronal differentiation
and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells.
Sonntag et al. Mol Cell Neurosci. March 28, 2005 Abstract
PDF
TGF alpha induced adult
neurogenesis does not produce dopamine neurons in PD model.
Cooper and Isacson J. Neurosci. October 13, 2004 Abstract
PDF
Generalized proteasome inhibition
in HD and convergent multiple cellular pathologies in vulnerable brain regions.
Seo et al. Ann. Neurol. September 2004 Abstract
PDF
Countway
Medical Library, Harvard University
|
.gif){kind=small}
